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Genetic and environmental factors both clearly play a role in narcolepsy-cataplexy. Until now, the best evidence for autoimmunity as a cause of the disorder was the discovery that nearly everyone with the disorder has unique variants of a gene called HLA-DQB1*0602. Generally, though, both the chip data sets [ 1 , 2 ] are broadly consistent with previous findings. We can also compare the chip data with those from studies of immune-responsive genes in mosquito cells, which give many similar results, including differential regulation of large numbers of serpins (serine-protease inhibitors), pattern-recognition proteins, such as the peptidoglycan recognition protein (PGRP) family, and effectors involved in melanization and coagulation, such as prophenol oxidase [ 4 ].
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Cells in the lining of body cavities produce fluids, such as saliva in the digestive system and mucus in the lungs, which provide a defense against harmful organisms. The body has its own natural, helpful organisms, which also prevent other more dangerous organisms from taking over. Cells of the immune system defending the body against both infectious disease and foreign materials. Five different types of white blood cells exist. Cell mediated immunity arises when T type lymphocytes come into contact with antigens and they are stimulated to produce antibodies. It takes 7-14 days for these to develop.
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